IN SILICO EVALUATION ON THE INTERACTION BETWEEN KETONE BODIES AND OBESITY-ASSOCIATED PROTEINS
- Project Research
- 1-5 Chapters
- Qualitative
- Library / Doctrinal
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
Background of study
Obesity, has been a pre-existing problem afore time but has been recognized as a global pandemic since the 21st century (Natalia, et al., 2021). Aronne, 2002 defines obesity as the anomalous, irregular or disproportionate gain of weight as a result of fat buildup in the body which adversely leads to the risk of several health related problems such as hypertension, type 2 diabetes, cardiovascular diseases and certain cancer types amongst others (Aronne, 2002; Natalia, et al., 2021; Williams, et al., 2015).
Obesity calculation is based on body mass index ≥ 30kg/m2 which is the measurement of fat buildup by dividing body mass (kg) by the square of the body height (m2) (Aronne, 2002; Kopelman, 2000). In 2016, WHO (world health organization) acknowledged that nearly 2-billion adults worldwide were measured to be overweight and 650 million of that population were found to be obese. The WHO, also estimated that 50% of the population found in Europe had preeminent body weight which could lead to obesity overtime (WHO, 2016).
Furthermore in 2002, certain rural areas in Nigeria were recorded to have a high rate of obesity at 33.7% (Ogah, 2013). Obesity mechanism, involves a complex process and certain physical and biochemical factors have been found to induce this condition some of which include unhealthy diets and eating habits, high calorie food consumption, genetic, epigenetic, and ecological factors. All these factors combined together with the lack of physical activity to burn excess body weight then lead to energy disproportion and fat deposition (William, et al., 2015; Lin, et al., 2017). Due to obesity prevalence overtime, several solutions and control measures have been brought up to ameliorate as well as control the condition. Some of these measures, include physical activity programmes, behavioral lifestyle programmes, pharmacotherapy, diet management, and in severe obese conditions bariatric surgery is recommended (Gonzalez-Muniesa, et al., 2017).
Caloric inhibition, a diet management scheme and nutritional strategy is the commonly used weight loss mechanism as far as diet management is concerned and this research focuses on the use of ketogenic diet which was used successfully in the therapy of epilepsy, as a control measure for obesity (Anton, et al., 2017; Ulamek-Koziol, et al., 2019).
Ketogenic diet is made up of an augmented fat content, minimal carbohydrate content and sufficient amount of protein content. As a result of the proportionate amount of nutrient in the diet composition, there is reduced metabolism of carbohydrate and protein but increased metabolism of fat (Kayode, et al., 2020).
Consequent fat breakdown and reduced carbohydrate and protein breakdown, then leads to reduced blood glucose levels and the stimulation of ketogenesis in the liver which produces increased levels of ketone bodies and fatty acids (Sanjay, et al., 2018; Kulaka and Polotsky, 2013). The resulting ketone bodies are then transported to the blood brain barrier to make available energy for the brain and increased levels of the ketone bodies lead to increased levels of substrates such as creatine, adenine triphosphate (ATP), and phosphocreatine that are essential in the brain (Kayode, et al., 2021; Sanjay, et al., 2018).
1.2 Statement of the Problem and objective of study
Obesity, is a predominant disease occurring in a yearly estimate of over 2 billion individuals as a result of excessive fat buildup and this has led to numerous health issues and conditions. With the prevalence of obesity in recent times, several control measures were proposed so as to ameliorate the condition. This study aims at exploring the efficiency of ketogenic diet generated ketone bodies in the prevention and amelioration of obesity using in silico simulations.
Related Project Materials
THE EFFECT OF POOR WORKING CONDITIONS ON THE PERFORMANCE OF AN OFFICE MANAGER
ABSTRACT
This study was carried out to examine the effect of poor working conditions on the performance of an office man...
EFFECT OF CORPORATE SOCIAL RESPONSIBILITY ON ORGANIZATION SURVIVAL
BACKGROUND OF THE STUDY
Corporate Social Responsibility is the responsibility of an organization for th...
TAX ADMINISTRATION IN NIGERIA; AN EVALUATION OF TAX EVATION AND AVOIDANCE
ABSTRACT
This study aims to evaluate the causes and effects of tax evasion and avoidance in Lagos state and proffering s...
MICROORGANISM ASSOCIATED WITH SPOILAGE OF TOMATOES (CANNED TOMATOES)
ABSTRACT
The micro-organism, associated with spoilage of tomatoes shows that tomato contain large amount of water which...
THE NIGER DELTA CRISIS – AN EVALUATION OF THE MANAGEMENT OF THE AMNESTY OPTION
ABSTRACT
Oil producing communities of Nigeria known as the Niger Delta region has been a region characterized with fierc...
E-MARKETING AND SMALL ENTERPRISE THREATS AND OPPORTUNITIES
ABSTRACT
The growth and spread of internet with an extraordinary pace over the last few decades has resulted in its increased use for mar...
PERSONAL SERVICES LOCATOR
ABSTRACT
In this Thesis, The Personal Services Locator helps users to find personalized workers or “Handymen” as fast as poss...
AN EVALUATION OF MONETARY POLICY AND ITS IMPACT ON BANKING ACHIEVEMENT IN NIGERIA
Background to the study
ACHIEVEMENT in the banking industry is influenced by a variety of external vari...
FACTORS HINDERING THE EFFECTIVE TEACHING OF VOCATIONAL COURSES IN NIGERIAN UNIVERSITIES
ABSTRACT
This study was carried out to examine the factors that hinder effective teaching and lear...
DEVELOPMENT OF THE AQUACULTURE COMPENDIUM
BACKGROUND TO THE STUDY
The Aquaculture Compendium is an encyclopedic, multimedia tool that brings tog...
